Clinical studies – Venocin®

Study 1

A placebo-controlled study explored the effects of supplementing with horse chestnut extract, standardized to contain 50 mg of escin per 300 mg capsule, taken twice daily for 12 weeks. The study aimed to observe the potential supportive effects of this supplementation on maintaining healthy circulations in limbs, particularly in comparison to the use of standard leg compression stockings, a common supportive measure for individuals focusing on circulatory wellness in the legs. Results from this research provide insights into how horse chestnut extract might support the body’s natural circulatory processes, contributing to the maintenance of leg health and comfort

The supplementation of the horse chestnut extract improved the condition and the effect was comparable to standard compression therapy with better compliance (Fig. 3).

venocin — **Figure 3. Effect of the extract on the lower leg volume compared to standard therapy**

Reference

Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet.1996;347(8997):292-294.

Study 2

A German multi-centric study engaged in a rigorous comparison of the clinical support provided by oxerutins and standardized horse chestnut extract for circulation health in limbs in women, particularly focusing on postmenopausal subjects. This double-blind, placebo-controlled study, which included 155 participants, with 37 completing the 19-week duration, aimed to investigate the potential benefits of these natural supplements on supporting circulatory wellness. The research, carefully designed with random allocation to different supplement groups, sought to provide insights into how each supplement might contribute to maintaining the health of the circulatory system

Oxerutins 1000 mg/day
Oxerutins 1000 mg/day initial dose for 4 weeks followed by 500 mg/day maintenance dose
Horse chestnut extract 600 mg/day (the supplement was supplied as capsules each containing 300 mg horse chestnut extract standardized to 50 mg escin/capsule)

One-week placebo run was followed by 12 weeks of the extract supplementation and a six weeks follow-up period without supplement. The extract showed effective reduction in leg volume (Fig. 4).

Figure 4. Effect of the extract and its combination with the oxerutin on the leg volume

Reference

Rehn D, Unkauf M, Klein P, Jost V, Lücker PW. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung. 1996;46(5):483-487.